Gamma oscillations precede interictal epileptiform spikes in the seizure onset zone

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Interictal high-frequency oscillations (100-500 Hz) in the intracerebral EEG of epileptic patients.

Interictal fast oscillations between 100 and 500 Hz have been reported in signals recorded from implanted microelectrodes in epileptic patients and experimental rat models. Oscillations between 250 and 500 Hz, or fast ripples (FR), appeared related to the epileptic focus whereas ripples (80-200 Hz) were not. We report high-frequency oscillations recorded with intracranial macroelectrodes in sev...

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Spectral bandwidth of interictal fast epileptic activity characterizes the seizure onset zone

The foremost aim of presurgical epilepsy evaluation is the delineation of the seizure onset zone (SOZ). There is increasing evidence that fast epileptic activity (FEA, 14-250 Hz) occurring interictally, i.e. between seizures, is predominantly localized within the SOZ. Currently it is unknown, which frequency band of FEA performs best in identifying the SOZ, although prior studies suggest highes...

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Interictal EEG spikes identify the region of electrographic seizure onset in some, but not all, pediatric epilepsy patients.

PURPOSE The role of sharps and spikes, interictal epileptiform discharges (IEDs), in guiding epilepsy surgery in children remains controversial, particularly with intracranial electroencephalography (IEEG). Although ictal recording is the mainstay of localizing epileptic networks for surgical resection, current practice dictates removing regions generating frequent IEDs if they are near the ict...

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Interictal Epileptiform Discharges

EEG remains the primary technique in the diagnosis, characterization, and localization of partial seizures. This review examines the significance and character of interictal epileptiform abnormailites, periodic lateralized epileptiform discharges, and ictal patterns in patients with partial epilepsy. Interictal epileptiform discharges are common and assist in the diagnosis and localization of p...

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How important is the seizure onset zone for seizure dynamics?

PURPOSE Research into epileptic networks has recently allowed deeper insights into the epileptic process. Here we investigated the importance of individual network nodes for seizure dynamics. METHODS We analysed intracranial electroencephalographic recordings of 86 focal seizures with different anatomical onset locations. With time-resolved correlation analyses, we derived a sequence of weigh...

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ژورنال

عنوان ژورنال: Neurology

سال: 2015

ISSN: 0028-3878,1526-632X

DOI: 10.1212/wnl.0000000000001234